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Skip to main page content home onlinefirst current issue past issues subscriptions alerts feedback aacr publications aacr home search go advanced search user name password sign in p38mapk-dependent sensitivity of ewing's sarcoma family of tumors to fenretinide-induced cell death stephen s. Myatt 1, christopher p. F. Redfern 2 and susan a. Burchill 1 authors' affiliations: 1candlelighter's children's cancer research laboratory, cancer research uk clinical centre, leeds, united kingdom and 2northern institute for cancer research, university of newcastle upon tyne, newcastle upon tyne, united kingdom requests for reprints: susan a. Burchill, candlelighter's children's cancer research laboratory, cancer research uk clinical centre, st. James's university hospital, beckett street, leeds ls9 7tf, united kingdom. Phone: 44-113-2065873; fax: 44-113-2429886; e-mail: s. A. Burchill{at}leeds. Ac. Uk. Abstract purpose: there is an urgent need for new therapeutic strategies in ewing's sarcoma family of tumors (esft). In this study, we have evaluated the effect of fenretinide [n-(4-hydroxyphenyl)retinamide] in esft models. Experimental design: the effect of fenretinide on viable cell number and apoptosis of esft cell lines and spheroids and growth of s. C. Esft in nu/nu mice was investigated. The role of the stress-activated kinases p38mapk and c-jun nh2-terminal kinase in fenretinide-induced death was investigated by western blot and inhibitor experiments. Accumulation of reactive oxygen species (ros) and changes in mitochondrial transmembrane potential were investigated by flow cytometry. Results: fenretinide induced cell death in all esft cell lines examined in a dose- and time-dependent manner. Esft cells were more sensitive to fenretinide than the neuroblastoma cell lines examined. Furthermore, fenretinide induced cell death in esft spheroids and delayed s. C. Esft growth in mice. buy cheap viagra viagra for sale cheap viagra online cheap viagra buy viagra online http://medicaresupplementspecialists.com/pfz-100-mg-generic-viagra-np/ nationalityinworldhistory.net/bsh-buy-online-viagra-so/ viagra discount discount viagra generic best price viagra for sale P38mapk was activated within 15 minutes of fenretinide treatment and was dependent on ros accumulation. Inhibition of p38mapk activity partially rescued fenretinide-mediated cell death in esft but not in sh-sy5y neuroblastoma cells. C-jun nh2-terminal kinase was activated. partners
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